The Critical Role of NAD+

NAD+ is naturally occurring coenzyme in all living life forms, found in every cell of the body and is essential in various metabolic processes.1

NAD+ diminishes with age. The decline of NAD+ levels during ageing has been scientifically linked to the onset of age related diseases.

“Ageing is characterized by a progressive decline of energy metabolism and physiological function, which serves as a major risk factor for several diseases, namely, cancer, cardiovascular disease, and neurodegenerative disease.”

Administration of NAD+ assists with the mitigation of such risks by increasing NAD+ levels in the body leading to improved health.1, 3, 4, 6

NAD+ serves as a vital co-factor and driving force for various critical cellular processes, such as energy metabolism, mitochondrial function, biosynthesis, gene expression, DNA repair, immune function and ageing.1, 4, 8, 9

  • Energy levels

    ‘Supplementation of specific food though the diet has been scientifically proven to increase NAD+ levels.

    This is because consumption of NAD+ precursors found in foods will increase NAD+ levels in human tissues.

    ‘NAD+ (nicotinamide adenine dinucleotide) is essential in energy production.

    NAD+ precursors, such as Niacin- found in meat, fish, and dairy products.

    NR (nicotinamide riboside)- found in milk and yeast.

    NMN (Nicotinamide mononucleotide (NMN)- found in edamame, broccoli, cabbage, cucumber, avocado, and tomato).10, 11, 12

  • Brain Health

    Declining NAD+ levels in the brain during ageing contributes to metabolic and cellular dysfunction and leads to age related neurological disorders. Scientific study shows benefit of oral supplementation with NR to raise NAD+ levels.5

    Another article but emphasis is on oral supplementation:

    Multiple clinical trials of NAD+ precursors, including NAM, NR, and NMN, in neurological disorders are in progress In some studies NR is shown to increase NAD + levels.7

  • Lower Risk of Age Related Conditions

    NAD+ levels naturally decrease with age. Pre clinical trials show that by replenishing NAD+ levels, improvement in cardiovascuar function, lower blood pressure and lower risk of heart failure. Overall promoting healthier ageing at the cellular level.15

  • Cellular Repair and Regeneration

    NAD+ plays a role in activating enzymes that may help in repairing and protecting DNA. This can be important for cell regeneration and overall health.2, 25, 26

  • Mood Regulation

    NAD+ has been clinically proven to have a role in regulating mood and alleviating symptoms of anxiety.16, 13

  • Essential for Metabolism

    NAD+ is essential for enzymes involved in cellular energy metabolism and the breakdown of glucose and fatty acids.1

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